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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRK All Species: 42.73
Human Site: S145 Identified Species: 78.33
UniProt: P42685 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42685 NP_002022.1 505 58254 S145 G S F L I R E S E S Q K G E F
Chimpanzee Pan troglodytes XP_518702 505 58217 S145 G S F L I R E S E S Q K G E F
Rhesus Macaque Macaca mulatta XP_001112190 505 58228 S145 G A F L I R E S E S Q K G E F
Dog Lupus familis XP_539091 505 57709 S149 G A F L I R E S E S Q K G D F
Cat Felis silvestris
Mouse Mus musculus Q922K9 512 58825 S152 G A F L I R E S E S Q K G D F
Rat Rattus norvegicus Q62662 506 58147 S146 G A F L I R E S E S Q K G D F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q02977 536 59984 S177 G T F L I R E S E T T K G A Y
Frog Xenopus laevis P13406 537 60828 S178 G T Y L I R E S E T T K G A Y
Zebra Danio Brachydanio rerio XP_695937 480 54879 L143 K H Y K I R K L D N G G Y Y L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V9J3 517 59051 S159 G A F L I R D S E S R H N D Y
Honey Bee Apis mellifera XP_396043 451 51726 A118 A K L K S I E A E P W Y F R K
Nematode Worm Caenorhab. elegans NP_493502 507 57512 S153 G A F L V R D S E S R Q H D L
Sea Urchin Strong. purpuratus NP_001135852 530 59779 S173 G S F L I R E S E S R V G D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 96.6 80.5 N.A. 88.6 88.3 N.A. N.A. 48.5 48.4 60.5 N.A. 56.8 51.6 50.4 56.6
Protein Similarity: 100 99.8 98 87.7 N.A. 92.9 93 N.A. N.A. 64.7 64.2 74 N.A. 73.3 67.1 69.4 70.5
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. N.A. 66.6 60 13.3 N.A. 53.3 13.3 46.6 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 86.6 86.6 40 N.A. 86.6 20 86.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 47 0 0 0 0 0 8 0 0 0 0 0 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 16 0 8 0 0 0 0 47 0 % D
% Glu: 0 0 0 0 0 0 77 0 93 0 0 0 0 24 0 % E
% Phe: 0 0 77 0 0 0 0 0 0 0 0 0 8 0 47 % F
% Gly: 85 0 0 0 0 0 0 0 0 0 8 8 70 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 0 0 0 0 85 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 8 0 16 0 0 8 0 0 0 0 62 0 0 8 % K
% Leu: 0 0 8 85 0 0 0 8 0 0 0 0 0 0 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 47 8 0 0 0 % Q
% Arg: 0 0 0 0 0 93 0 0 0 0 24 0 0 8 0 % R
% Ser: 0 24 0 0 8 0 0 85 0 70 0 0 0 0 0 % S
% Thr: 0 16 0 0 0 0 0 0 0 16 16 0 0 0 0 % T
% Val: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 16 0 0 0 0 0 0 0 0 8 8 8 31 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _